Indicators of Acute Kidney Injury as Biomarkers to Differentiate Heatstroke from Coronavirus Disease 2019: A Retrospective Multicenter Analysis

Background: Coronavirus disease 2019 (COVID-19) and heat-related illness are systemic febrile diseases. These illnesses must be differentiated during a COVID-19 pandemic in summer. However, no studies have compared distinguished COVID-19. We data from patients with early those Methods: This retrospective observational study included 90 selected the Heatstroke STUDY 2017-2019 (nationwide registries of Japan) 86 laboratory-confirmed who had fever or fatigue were admitted to one two hospitals Tokyo, Japan. Results: Among vital signs, systolic blood pressure (119 vs. 125 mm Hg, p = 0.02), oxygen saturation (98% 97%, < 0.001), body temperature (36.6°C 37.6°C, p<0.001) showed significant between-group differences heatstroke groups, respectively. The numerous intergroup laboratory findings disparities white cell count (10.8 × 103/μL 5.2 103/μL, p<0.001), creatinine (2.2 0.85 mg/dL, C-reactive protein (0.2 2.8 although logistic regression model achieved an area under curve (AUC) 0.966 using these three factors. A Random Forest machine learning accuracy, precision, recall, AUC 0.908, 0.976, 0.842, 0.978, Creatinine was most important feature this model. Conclusions: Acute kidney injury associated illness, which could essential distinguishing evaluating summer pandemic.